… We therefore aimed to compare the frequency of thromboembolism after total knee
replacement in patients who were randomized to be managed postoperatively with
edoxaban thromboprophylaxis (both groups) with or without use of the foot pump. We also
sought to evaluate these roconversion rates of anti-PF4/heparin antibodies in these patients. …
In conclusion, our randomized controlled study demonstrated that combined
pharmacological (edoxaban) and mechanical prophylaxis (a foot pump) did not reduce the …

We conducted a randomized clinical trial to compare the effectiveness of the AV Impulse
System foot pump for reducing the incidence of deep-vein thrombosis (DVT) after total knee
arthroplasty (TKA) in patients under edoxaban thromboprophylaxis. Patients undergoing
primary TKA at our institution between September 2013 and March 2015 were enrolled after
obtaining informed consent. The patients were randomized to use the foot pump (n ¼ 58)
and not to use the foot pump (n ¼ 62). Both groups were given prophylactic edoxaban …